abstract：OBJECTIVE:To evaluate the efficacy of different lung recruitment maneuvers using electric impedance tomography. DESIGN AND SETTING:Experimental study in animal model of acute lung injury in an animal research laboratory. SUBJECTS:Fourteen pigs with saline lavage induced lung injury. INTERVENTIONS:Lung volume, region...

journal_title：Intensive care medicine

authors： Odenstedt H,Lindgren S,Olegård C,Erlandsson K,Lethvall S,Aneman A,Stenqvist O,Lundin S

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:To determine the impact of missing Acute Physiology Score (APS) values on risk-adjusted mortality. DESIGN:Retrospective review of prospectively collected Acute Physiology and Chronic Health Evaluation (APACHE) III database. SETTING:The intensive care units (ICUs) of an academic medical center. PATIENTS:38,...

journal_title：Intensive care medicine

authors： Afessa B,Keegan MT,Gajic O,Hubmayr RD,Peters SG

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:The Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy related to autoimmunity. However, no conclusive etiological concept has yet been found. We examined the variation in autoantibodies to lipids in serum of GBS patients in response to the course of the disease but investigated titer modif...

journal_title：Intensive care medicine

authors： Nakos G,Tziakou E,Maneta-Peyret L,Nassis C,Lekka ME

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:To assess the value of the diagnosis of overt disseminated intravascular coagulation (DIC) according to the International Society on Thrombosis and Haemostasis (ISTH) criteria and that of the parameters included in the ISTH score for overt DIC in predicting day 28 mortality in intensive care patients. Also, t...

journal_title：Intensive care medicine

authors： Sivula M,Tallgren M,Pettilä V

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of screening strategy and contact precautions for patients with methicillin-resistant Staphylococcus aureus (MRSA). DESIGN AND SETTING:Prospective observational cohort from 1 February 1995 to 31 December 2001 in three intensive care units (45 beds) in a French teaching hospital....

journal_title：Intensive care medicine

authors： Lucet JC,Paoletti X,Lolom I,Paugam-Burtz C,Trouillet JL,Timsit JF,Deblangy C,Andremont A,Regnier B

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:To investigate the involvement of intestinal angiotensin II type 2 receptors in the outcome of acute severe hypovolemia as well as systemic and regional mesenteric hemodynamics and intestinal mucosal functions in anesthetized pigs. DESIGN AND SETTING:Prospective, interventional animal study in a university r...

journal_title：Intensive care medicine

authors： Laesser M,Spak E,Ewert S,Aneman A,Fandriks L

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:To assess the impact of hemodynamic variables on the outcome of critically ill patients in septic shock and to identify the optimal threshold values related to outcome with special reference to continuously monitored mean arterial pressure (MAP) and mixed venous oxygen saturation (SvO2). DESIGN AND SETTING:R...

journal_title：Intensive care medicine

authors： Varpula M,Tallgren M,Saukkonen K,Voipio-Pulkki LM,Pettilä V

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of 70-mg and 200-mg doses of intravenous erythromycin in improving gastric emptying in critically ill patients. DESIGN:Gastric emptying was measured on consecutive days; day 1 (pre-treatment), day 2 (post-treatment) after an intravenous infusion of either 70 or 200 mg erythromyci...

journal_title：Intensive care medicine

authors： Ritz MA,Chapman MJ,Fraser RJ,Finnis ME,Butler RN,Cmielewski P,Davidson GP,Rea D

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:To determine the clinical impact of bedside colonoscopy for critically ill patients with acute lower gastrointestinal (GI) bleeding. DESIGN AND SETTING:A 3-year retrospective analysis (chart review). Medical intensive care unit (ICU) of a 1,312-bed tertiary-care center in Taiwan. PATIENTS AND PARTICIPANTS:F...

journal_title：Intensive care medicine

authors： Lin CC,Lee YC,Lee H,Lin JT,Ho WC,Chen TH,Wang HP

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence of relative adrenal insufficiency in patients successfully resuscitated after cardiac arrest, and its prognostic role in post-resuscitation disease. DESIGN AND SETTING:A prospective observational single-center study in a medical intensive care unit. PATIENTS:64 patients hospitalised...

journal_title：Intensive care medicine

authors： Pene F,Hyvernat H,Mallet V,Cariou A,Carli P,Spaulding C,Dugue MA,Mira JP

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of traditional and online teaching methods for educating anesthesiology residents in the principles and practice of difficult airway management. DESIGN:Prospective, randomized, controlled trial. SETTING:University hospital. PARTICIPANTS:Two randomly selected groups, each contai...

journal_title：Intensive care medicine

authors： Bello G,Pennisi MA,Maviglia R,Maggiore SM,Bocci MG,Montini L,Antonelli M

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of two different comorbidity measures on the 6-month mortality of severely ill cancer patients. DESIGN AND SETTING:Prospective cohort study in a ten-bed oncological medical-surgical intensive care unit (ICU). PATIENTS:A total of 772 consecutive patients were included over a 45-month p...

journal_title：Intensive care medicine

authors： Soares M,Salluh JI,Ferreira CG,Luiz RR,Spector N,Rocco JR

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:Endotracheal suctioning can cause alveolar collapse and impede ventilation. One reason is the gas flow through a single-lumen endotracheal tube (ETT) provoking a gradient between airway opening and tracheal (P(tr)) pressures. Separately extending the patient tubing limbs of a suitable ventilator into the trac...

journal_title：Intensive care medicine

authors： Reissmann H,Böhm SH,Suárez-Sipmann F,Tusman G,Buschmann C,Maisch S,Pesch T,Thamm O,Plümers C,Schulte am Esch J,Hedenstierna G

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:The long-term mortality outcome associated with sepsis and septic shock has not been well defined in a nonselected critically ill population. This study investigated the occurrence and the role of bloodstream infection (BSI) associated sepsis and septic shock at time of intensive care unit (ICU) admission on ...

journal_title：Intensive care medicine

authors： Laupland KB,Zygun DA,Doig CJ,Bagshaw SM,Svenson LW,Fick GH

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:To assess acute cardiorespiratory effects of recruitment manoeuvres in experimental acute lung injury. DESIGN:Experimental study in animal models of acute lung injury. SETTING:Experimental laboratory at a University Medical Centre. ANIMALS:Ten pigs with bronchoalveolar lavage and eight pigs with endotoxin-...

journal_title：Intensive care medicine

authors： Odenstedt H,Aneman A,Kárason S,Stenqvist O,Lundin S

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Changes in body temperature have important impact on measurements of blood gases. In blood gas analyzers the samples are always kept constant at a temperature of exactly 37 degrees C during the measurements, and therefore results are not correct if body temperature differs from 37 degrees C. OBJECTIVE:Lack ...

journal_title：Intensive care medicine

authors： Bacher A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Fibroproliferation markers like procollagen I predict mortality in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). We sought to determine whether bronchoalveolar lavage fluid (BALF) from patients with lung injury contained mediators that would activate procollagen I promo...

journal_title：Intensive care medicine

authors： Budinger GR,Chandel NS,Donnelly HK,Eisenbart J,Oberoi M,Jain M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Endotoxin administration to humans is a common means to study systemic inflammation. Worldwide, thousands of volunteers have received endotoxin, and adverse events are rarely reported. The aim of this report was to increase awareness of specific risks of the intravenous administration of endotoxin to human vo...

journal_title：Intensive care medicine

authors： van Eijk LT,Pickkers P,Smits P,Bouw MP,van der Hoeven JG

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To describe the use of volumetric capnography, a plot of expired CO(2) concentration against expired volume, in monitoring fibrinolytic treatment of major pulmonary embolism. DESIGN AND SETTING:Two case reports in the emergency department of a teaching hospital. PATIENTS:Two conscious and spontaneously brea...

journal_title：Intensive care medicine

authors： Verschuren F,Heinonen E,Clause D,Roeseler J,Thys F,Meert P,Marion E,El Gariani A,Col J,Reynaert M,Liistro G

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:The primary objective was to test the hypothesis that clinical re-expansion pulmonary edema is predominantly due to increased permeability of the alveolar-capillary barrier. A secondary objective was to determine if the alveolar epithelium was functionally intact in patients with re-expansion pulmonary edema ...

journal_title：Intensive care medicine

authors： Sue RD,Matthay MA,Ware LB

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:To evaluate various treatment strategies in critically ill patients with ischaemic acute renal failure, there is a need for reliable bedside measurements of total renal blood flow (RBF), glomerular filtration rate (GFR) and renal oxygen consumption without the need for urine collection. DESIGN:The continuous...

journal_title：Intensive care medicine

authors： Swärd K,Valsson F,Sellgren J,Ricksten SE

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the extent to which respiratory changes in inferior vena cava (IVC) diameter can be used to predict fluid responsiveness. DESIGN:Prospective clinical study. SETTING:Hospital intensive care unit. PATIENTS:Twenty-three patients with acute circulatory failure related to sepsis and mechanically ven...

journal_title：Intensive care medicine

authors： Barbier C,Loubières Y,Schmit C,Hayon J,Ricôme JL,Jardin F,Vieillard-Baron A

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:We perform an ethical analysis of European Union Directive 2001/20/EC on the simplification and harmonization of guidelines regarding good clinical practice in the conduct of clinical trials involving drugs. BACKGROUND:The Directive provides guidance on protecting incapacitated subjects who participate in dr...

journal_title：Intensive care medicine

authors： Silverman HJ,Druml C,Lemaire F,Nelson R,European Union Directive.

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To analyze the effects of polymyxin B-immobilized fiber (PMX-F) on bone resorption in septic patients. DESIGN AND SETTING:Observational prospective study in intensive care units of a general hospital. PATIENTS AND PARTICIPANTS:25 patients with severe sepsis and 20 healthy controls. MEASUREMENTS AND RESULTS...

journal_title：Intensive care medicine

authors： Nakamura T,Kawagoe Y,Matsuda T,Koide H

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To assess noise exposure during noninvasive ventilation (NIV) with different types of interface (helmet, nasal, and facial masks). SUBJECTS AND METHODS:Ten "naive" healthy volunteers underwent NIV at pressure support levels of 10 and 15 cmH2O with: (a) helmet, (b) helmet equipped with HME filters at the junc...

journal_title：Intensive care medicine

authors： Cavaliere F,Conti G,Costa R,Proietti R,Sciuto A,Masieri S

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients. DESIGN:Prospective clinical study. SETTING:Medical ICU of a non-university hospital. PATIENTS:Mechanically ventilated patients with sep...

journal_title：Intensive care medicine

authors： Feissel M,Michard F,Faller JP,Teboul JL

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate and compare the accuracy of the percentage of infected cells (%IC) in bronchoalveolar lavage (BAL) for ventilator-associated pneumonia (VAP) diagnosis according to its onset from the initiation of mechanical ventilation. PATIENTS:One hundred and eight patients admitted ...

journal_title：Intensive care medicine

authors： Dupont H,Chalhoub V,Plantefève G,De Vaumas C,Kermarrec N,Paugam-Burtz C,Mantz J

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:On hospital admission, the morphology of the central pulmonary artery thromboemboli is an independent predictor of 30-day mortality in patients with massive pulmonary embolism (MPE). This may be due to the differential susceptibility of thromboemboli to thrombolysis. The aim of this study was to assess haemod...

journal_title：Intensive care medicine

authors： Podbregar M,Voga G,Krivec B

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:To describe hyperglycaemia as a possible marker of morbidity and mortality in critically ill medical and surgical patients admitted to a multidisciplinary ICU. DESIGN:Prospective cohort study. SETTING:A 13-bed non-cardiac multidisciplinary ICU in a university hospital. PATIENTS AND PARTICIPANTS:Adult patie...

journal_title：Intensive care medicine

authors： Christiansen C,Toft P,Jørgensen HS,Andersen SK,Tønnesen E

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:Nuclear factor-kappaB (NF-kappaB) is a transcription factor which plays a pivotal role in the induction of genes involved in the response to injury and inflammation. Calpain I inhibitor is a potent antioxidant which is an effective inhibitor of NF-kappaB. This study examined whether the postulate that calpain...

journal_title：Intensive care medicine

authors： Virlos I,Mazzon E,Serraino I,Genovese T,Di Paola R,Thiemerman C,Siriwardena A,Cuzzocrea S

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:The most recent approach to estimate nursing resources consumption has led to the generation of the Nine Equivalents of Nursing Manpower use Score (NEMS). The objective of this prospective study was to establish a completely automatically generated calculation of the NEMS using a patient data management syste...

journal_title：Intensive care medicine

authors： Junger A,Brenck F,Hartmann B,Klasen J,Quinzio L,Benson M,Michel A,Röhrig R,Hempelmann G

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To test the feasibility of the transcardiac conductance (TCC) method for continuous, on-line measurement of absolute left ventricular (LV) volume and to validate the method by comparison with biplane angiography. DESIGN AND SETTING:Prospective clinical feasibility and validation study in a cardiac catheteriz...

journal_title：Intensive care medicine

authors： Staal EM,Baan J,Jukema JW,van der Wall EE,Steendijk P

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:To study the pattern of lung emptying and expiratory resistance in mechanically ventilated patients with chronic obstructive pulmonary disease (COPD). DESIGN:A prospective physiological study. SETTING:A 12-bed Intensive Care Unit. PATIENTS:Ten patients with acute exacerbation of COPD. INTERVENTIONS:At th...

journal_title：Intensive care medicine

authors： Kondili E,Alexopoulou C,Prinianakis G,Xirouchaki N,Georgopoulos D

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:To assess the reproducibility of respiratory dead space measurements in ventilated children. DESIGN:Prospective study. SETTING:University pediatric intensive care unit. PATIENTS:Thirty-two mechanically ventilated children (0.13-15.4 years) who were clinically stable. METHODS:The single-breath CO(2) test ...

journal_title：Intensive care medicine

authors： Riou Y,Leclerc F,Neve V,Dupuy L,Noizet O,Leteurtre S,Sadik A

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:Pseudomonas aeruginosa-induced lung injury is characterized not only by the alteration in lung fluid movement but also by apoptosis of lung epithelial and endothelial cells. We studied whether inhibition of apoptosis using a broad spectrum caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp fluoromethylketone (Z...

journal_title：Intensive care medicine

authors： Le Berre R,Faure K,Fauvel H,Viget NB,Ader F,Prangère T,Thomas AM,Leroy X,Pittet JF,Marchetti P,Guery BP

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:To determine the steady-state plasma and epithelial lining fluid (ELF) concentrations of ceftazidime administered in continuous infusion to critically ill patients with severe nosocomial pneumonia. DESIGN:Prospective, open-label study. SETTING:An intensive care unit and research ward in a university hospita...

journal_title：Intensive care medicine

authors： Boselli E,Breilh D,Rimmelé T,Poupelin JC,Saux MC,Chassard D,Allaouchiche B

更新日期：2004-05-01 00:00:00

abstract：:Induced hypothermia can be used to protect the brain from post-ischemic and traumatic neurological injury. Potential clinical applications and the available evidence are discussed in a separate paper. This review focuses on the practical aspects of cooling and physiological changes induced by hypothermia, as well as t...

journal_title：Intensive care medicine

authors： Polderman KH

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To compare the effects of a cerebral perfusion pressure (CPP) intervention achieved with dopamine and norepinephrine after severe head injury. DESIGN:Prospective, controlled, trial. SETTING:Neurosciences critical care unit. PATIENTS:Eleven patients with a head injury, requiring dopamine or norepinephrine i...

journal_title：Intensive care medicine

authors： Johnston AJ,Steiner LA,Chatfield DA,Coles JP,Hutchinson PJ,Al-Rawi PG,Menon DK,Gupta AK

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To determine the incidence, risk factors, and outcome of barotrauma in a cohort of mechanically ventilated patients where limited tidal volumes and airway pressures were used. DESIGN AND SETTING:Prospective cohort of 361 intensive care units from 20 countries. PATIENTS AND PARTICIPANTS:A total of 5183 patie...

journal_title：Intensive care medicine

authors： Anzueto A,Frutos-Vivar F,Esteban A,Alía I,Brochard L,Stewart T,Benito S,Tobin MJ,Elizalde J,Palizas F,David CM,Pimentel J,González M,Soto L,D'Empaire G,Pelosi P

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:Pressure measurements at the level of the right atrium are commonly used in clinical anesthesia and the intensive care unit (ICU). There is growing interest in the use of peripheral venous sites for estimating central venous pressure (CVP). This study compared bias, precision, and covariance in simultaneous m...

journal_title：Intensive care medicine

authors： Desjardins R,Denault AY,Bélisle S,Carrier M,Babin D,Lévesque S,Martineau R

更新日期：2004-04-01 00:00:00